Lü Laboratory

Selected Publications

* co-first author
# co-corresponding author

Ruan Z*, Osei-Owusu J*, Du J, Qiu Z#, Lü W#. 2020. Structures and pH-sensing mechanism of the proton-activated chloride channel. Nature.

Ruan Z, Orozco IJ, Du J#, Lü W#. 2020. Structures of human Pannexin 1 reveal ion pathways and mechanism of gating. Nature.

Huang Y, Fliegert R, Guse AH, Lü W#, Du J#. 2019. A structural overview of the ion channels of the TRPM family. Cell Calcium.

Choi W*, Clemente N*, Sun W, Du J#, Lü W#. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.

Yu J, Zhu H, Lape R, Greiner T, Shahoei R, Wang Y, Du J, Lü W, Tajkhorshid E, Sivilotti L, Gouaux E. In press. Mechanism of gating and partial agonist action in the glycine receptor. BioRxiv.

Haung Y, Roth B, Lü W#, Du J#. 2019. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. eLife.

Haley E, Choi W, Fan C, Sun W, Du J, Lü W. 2019. Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy. J Vis Exp (143):e58754, doi:10.3791/58754.

Huang Y, Winkler PA, Sun W, Lü W#, Du J#. 2018. Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature.

Fan C*, Choi W*, Sun W, Du J#, Lü W#. 2018. Structure of the human lipid-gated cation channel TRPC3. eLife:e36852.

Winkler PA*, Huang Y*, Sun W*, Du J, Lü W. 2017. Electron cryo-microscopy structure of a human TRPM4 channelNature.

Lü W*, Du J*, Goehring A, Gouaux E. 2017. Cryo-EM structure of the triherteromeric NMDA receptor and its allosteric modulationScience 355(6331):eaal3729.

Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E. 2016. X-ray structures define human P2X(3) receptor gating cycle and antagonist actionNature 538(7623):66–71.

Du J*, Lü W*, Wu S, Cheng Y, Gouaux E. 2015. Glycine receptor mechanism elucidated by electron cryo-microscopyNature 526 (7572):224–229.       

Rycovska-Blume A, Lü W, Andrade S, Fendler K, Einsle O. 2015. Structural and functional studies of NirC from Salmonella typhimuriumMethods Enzymol556:475–497.

Lee CH*, Lü W*, Michel JC, Goehring A, Du J, Song X, Gouaux E. 2014. NMDA receptor structures reveal subunit arrangement and pore architecture. Nature 511(7508):191–197.      

Lü W, Du J, Schwarzer NJ, Wacker T, Andrade SL, Einsle O. 2013. The formate/nitrite transporter family of anion channelsBiol Chem 394(6):715–727.

Lü W, Schwarzer NJ, Du J, Gerbig-Smentek E, Andrade SL, Einsle O. 2012. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimuriumProc Natl Acad Sci U S A. 109(45):18395–18400.

Lü W, Du J, Schwarzer NJ, Gerbig-Smentek E, Einsle O, Andrade SL. 2012. The formate channel FocA exports the products of mixed-acid fermentationProc Natl Acad Sci U S A 109(33):13245–13259.

Guttenberg G, Hornei S, Jank T, Schwan C, Lü W, Einsle O, Papatheodorou P, Aktories K. 2012. Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells. J Biol Chem 287(30):24929–24940.

Du J*, Say RF*, Lü W, Fuchs G, Einsle O. 2011. Active-site remodeling in the bifunctional fructose-1,6-biphosphate aldolase/phosophotaseNature 478(7370):534–537.     

Guttenberg G, Papatheodorou P, Genisyuerek S, Lü W, Jank T, Einsle O, Aktories K. 2011. Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxinJ Biol Chem 286(17):14779–14789.

Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O. 2011. pH-dependent gating in a FocA formate channelScience 332(6027):352–354.

Maier S, Schleberger P, Lü W, Wacker T, Pflüger T, Litz C, Andrade SL. 2011. Mechanism of disruption of the Amt-GInK complex by P(II)-mediated sensing of 2-oxoglutaratePLoS One 6(10):e26327.

Helfmann S, Lü W, Litz C, Andrade SL. 2010. Cooperative binding of MgATP and MgADP in the trimeric P(II) protein GInK2 from Archaeoglobus fulgidusJ Mol Biol 402(1):165–177.

Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O. 2010. Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumonphilaJ Mol Biol 396(2):321–331.